Curious
Here is the issue:
Pithos running for Pandora - Audio Output fine.
Plug in SignaLink usb soundcard for decoding signals on HF - and the audio settings change. Pithos tries to route audio to it.
Due to this change - the computer can't key the radio correctly.
If Pithos is running, and the Singlalink is connected, changing the volume will key cycle the radio (transmit/receive/transmit) which is not healthy on the radio.