@xavierdelaraunt said in User Profile handling anno 2022:

I have quite a lot of settings I cannot get into the default settings in any way like that.

I have not ran into any policies, settings, etc that could not be don't through Intune. It would be very hard for me to think of something that I can't do to a device related to those through Intune.

If you are referring to user profile migrations across different devices (old device > new device), most of that can be resolved by better systemic practices prior. That can be a shitty experience regardless of MDM or device management system.