@aaron @BBigford
Hola! My name is Christopher and I am one of the senior support guys @ Backblaze. Just want to clarify a few points, as it seems there's a little confusion.
Under the "Continuous" backup schedule setting (the default), the Backblaze software will automatically index the computer for new or changed files roughly once every 1-2 hours, depending on the system configuration. Following the completion of each indexing cycle, the Backblaze software will upload all the new or changed files that were just indexed. Once a file has been uploaded, it can take 1-2 hours for the file to appear and be available for restore through the Backblaze website.
In regards to open files, this is generally not an issue unless the file has not actually been saved to disk OR the application locks or prevents other applications from reading the file on disk (like Outlook does, for example). So long as the Backblaze software has the ability to read the file, it should be able to be included in the following Backblaze backup. We do not support VSS/Shadowcopy.
It's likely worth noting that any time the computer is shutdown or asleep, neither the file indexing nor upload processes can run. The user's power settings and usage patterns may effect the frequency with which either the indexing or upload processes complete.