Best way to run Chrome on 2016 RDS.

Use this as a reference.

https://support.google.com/chrome/a/answer/187202?hl=en

Use enterprise edition and configure admx with GPO

Set
Disk Cache Directory
Roaming Profiles Directory
User Data Directory
Setting up Legacy Browsers and Plugin
Turning off Hardware accel and other settings for performance.

Just read that and configure what policies you need. Took me a day to set up but works smooth.