Had a look at nodeweaver's website - https://www.nodeweaver.eu
It looks interesting. They have a clear edge computing, IoT, Industry 4.0 focus on their product and their customers. So it's not a generic IT HCI product but rather geared towards those types of applications.
So what's the difference really? Well, the difference is that it's probably going to be managed by technicians and not IT. So it's design is likely geared towards easy of use and stability rather than towards bleeding edge features and lots of settings.
And also possibly tuned to run on very modest hardware as that is common feature of edge devices. It's also very likely that it is tuned for deterministic real time applications, which is common on edge devices and IIoT. KVM has PREEMPT-RT which are patches to give better performance for real time applications. Basically you want to know that an application will respond within a certain time, every time, regardless of what it is doing.
So this could be a good thing or a bad thing. Most things like real time patches improves things where it is needed but doesn't cause much performance loss where it is not needed. Anyway, as a product I think if you want a turn-key system it will probably be a good fit. If you want to be able to tinker with everything it will probably not be the right choice.